A prospective randomized study comparing bipolar plasmakinetic transurethral resection of the prostate and monopolar transurethral resection of the prostate for the treatment of Benign Prostatic Hyperplasia: efficacy, sexual function, Quality of Life, and complications

Objective: To generate high-quality data comparing the clinical efficacy and safety profile between monopolar transurethral resection of prostate (M-TURP) bipolar plasmakinetic (PK-TURP) for benign prostatic hyperplasia (BPH). Materials Methods: Prospective, randomized, single-blinded study conducted in a tertiary-care public institution (Dec/2014-Aug/2016). Inclusion criteria: <80g patients with drug-refractory lower urinary tract symptoms (LUTS), complications derived from BPH, or both. Exclusion history pelvic surgery/radiotherapy, neurogenic bladder dysfunction documented/suspected carcinoma. Treatment evaluated at 1, 3, 6 12 months. Efficacy outcomes: international symptom score (IPSS), quality-of-life (QoL) score, index erectile function-5 (IIEF-5), maximum flow rate (Qmax), postvoid residual urine (PVRU) volume, volume (PV). Complications sequelae also assessed. Comparisons performed parametric/non-parametric tests. Results: Out 100 hundred patients, 84 qualified analysis (45 M-TURP/39 PK-TURP). No significant differences found baseline characteristics operative data, except longer time PK-TURP (MD:7.9min; 95%CI:0.13-15.74; p=0.04). IPSS, Qmax PVRU volume. QoL months was higher (MD:0,9points; 95%CI:0.18-1.64; p=0.01). sexual function, PV, were found. This is “rigorous” (Jadadscale) has low risk bias (Cochrane-Handbook). Conclusions: Based on this controlled trial, there not variation effectiveness M-TURP treatment BPH. The small difference one-year follow-up perceivable by and, therefore, clinically relevant.